Which topical lubricant inhibits T cell activation by preventing the production of IL-2?

The correct answer is Restasis, which contains cyclosporine A as its active ingredient. Cyclosporine A works by inhibiting T cell activation, primarily through its action on interleukin-2 (IL-2) production. IL-2 is a critical cytokine that promotes the growth, proliferation, and differentiation of T cells.

In the context of treating dry eye disease, Restasis is utilized because it helps to increase tear production in patients who have a condition associated with ocular inflammation. By inhibiting T cell activation and reducing the production of pro-inflammatory cytokines like IL-2, Restasis helps to modify the underlying inflammatory process that contributes to dry eye.

This action makes Restasis unique compared to other topical lubricants that may provide symptomatic relief but do not address the underlying inflammatory mechanisms. Therefore, while standard lubricants provide moisture, Restasis functions on a deeper level to modulate the immune response in the ocular surface, which is essential for patients suffering from chronic dry eye.