Which of the following prostaglandins is used most commonly for treating glaucoma?

Latanoprost is the most commonly used prostaglandin analogue for treating glaucoma due to its efficacy and favorable side effect profile. As a prostaglandin F2α analogue, it works by increasing the outflow of aqueous humor through the uveoscleral pathway, leading to a reduction in intraocular pressure (IOP). It is typically dosed once daily, which enhances patient adherence compared to medications that require multiple daily doses.

Prostaglandin analogues, including Latanoprost, are often preferred in glaucoma therapy because they are effective for most patients. They tend to have a longer duration of action, which allows for convenient once-daily dosing, helping patients manage their condition more effectively. Additionally, Latanoprost is often favored in clinical practice due to its well-documented safety profile and established long-term efficacy in managing chronic open-angle glaucoma.

While Bimatoprost, Travoprost, and Unoprostone are also used in the treatment of glaucoma, Latanoprost remains the first-line choice in many cases, largely due to its widespread use and clinical experience accumulated over the years.