Which of the following pharmacologic agents is primarily indicated for reducing intraocular pressure?

The pharmacologic agent that is primarily indicated for reducing intraocular pressure is beta-blockers. In the context of ophthalmology, beta-blockers, such as timolol and betaxolol, are commonly utilized in the management of glaucoma and ocular hypertension. These medications work by decreasing the production of aqueous humor in the anterior chamber of the eye, which helps to lower intraocular pressure.

Topical NSAIDs are primarily used for their anti-inflammatory and analgesic properties in conditions such as postoperative pain or inflammation but do not have a significant effect on intraocular pressure. Topical steroids are used to reduce inflammation and manage ocular conditions like allergic reactions, but they can potentially increase intraocular pressure if used long-term. Mydriatics, which are medications used to dilate the pupil, primarily play a role in diagnostic procedures or treating ocular conditions, but do not contribute to lowering intraocular pressure. Therefore, beta-blockers are the most appropriate choice for the indication of reducing intraocular pressure.