Which of the following is NOT an example of a topical NSAID?

Bepotastine (Bepreve) is not classified as a topical NSAID; rather, it is an antihistamine used primarily for the treatment of allergic conjunctivitis. It works by blocking the effects of histamine at H1 receptors, thus alleviating symptoms like itching and redness associated with eye allergies.

In contrast, flurbiprofen, nepafenac, and ketorolac tromethamine are indeed topical NSAIDs and are used to manage pain and inflammation in various ocular conditions. Flurbiprofen, for example, is often used prior to surgery to reduce miosis, while nepafenac and ketorolac tromethamine are commonly utilized for post-operative inflammation and pain management. This distinguishes bepoteastine from the other options, which are directly involved in the inhibition of cyclooxygenase enzymes, thereby reducing the production of prostaglandins associated with pain and inflammation.