Which of the following is NOT a known side effect of Brimonidine?

Brimonidine is an alpha-2 adrenergic agonist commonly used in the treatment of glaucoma. It is known for its ability to lower intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. One of the interesting aspects of Brimonidine is its side effect profile.

Miosis, or constricted pupils, is a known side effect of Brimonidine due to its action on alpha receptors in the iris dilator muscle. Follicular conjunctivitis can occur as a hypersensitivity reaction and is also recognized as a potential side effect. Dry mouth is associated with the systemic absorption of the drug and stimulation of adrenergic receptors, leading to decreased salivation.

Mydriasis, or dilated pupils, is not a known side effect of Brimonidine. This is primarily because Brimonidine acts as an alpha-2 agonist, which typically causes miosis rather than mydriasis. Therefore, identifying mydriasis as a side effect of Brimonidine is incorrect.