Which are the main topical Cholinergic Antagonists associated with the pneumonic STop ACH?

The correct choice identifies the main topical cholinergic antagonists as Scopolamine, Tropicamide, Atropine, and Cyclopentolate. Each of these agents plays a notable role in ocular pharmacology.

Scopolamine is widely used for its ability to induce mydriasis (dilation of the pupil) and for its therapeutic effects in motion sickness. Tropicamide is another common agent used primarily in ophthalmic practice for dilating the pupil, thanks to its rapid onset and relatively short duration of action. Atropine is a classic anticholinergic drug that significantly dilates the pupil and is often used in various therapeutic scenarios, including amblyopia treatment. Cyclopentolate, known for its ability to induce cycloplegia (paralysis of the ciliary muscle), is important in both diagnostics and treatments within the eye care field.

These agents are categorized as cholinergic antagonists because they block the action of acetylcholine at the muscarinic receptors, which is the basis of their pharmacological effect. The mnemonic "STop ACH" is a helpful way to remember these drugs, aligning with their role in inhibiting the actions of acetylcholine. The grouping of these specific agents highlights their prominence