When are Prostaglandin Analogs typically dosed?

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Prostaglandin analogs, which are commonly used in the treatment of glaucoma and ocular hypertension, are typically administered at night. This dosing schedule is primarily due to their mechanism of action and the diurnal variation of intraocular pressure (IOP). Prostaglandins increase the outflow of aqueous humor, which is most effective during the nighttime when IOP naturally tends to be higher in many patients. Administering these medications at night helps to maximize their effectiveness during the period of peak IOP.

Additionally, dosing at night can also enhance patient adherence, as patients may find it more convenient to incorporate the medication into their bedtime routine. The once-daily dosing of prostaglandin analogs further supports patient compliance and improves overall treatment outcomes. These factors underscore why nighttime is the preferred dosing period for this class of medication.

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