What is the only topical Alpha 1 adrenergic agonist recognized on the NBEO matrix?

Phenylephrine is the only topical Alpha 1 adrenergic agonist recognized on the NBEO matrix. This agent primarily acts on alpha-1 receptors, leading to vasoconstriction and increased pupil size (mydriasis) when applied topically to the eye. It is commonly used in ophthalmic practice for dilating the pupil during examinations or procedures due to its effectiveness and relatively short duration of action.

In contrast, other agents listed, such as Brimonidine and Apraclonidine, primarily act as alpha-2 adrenergic agonists. Brimonidine is primarily employed for managing intraocular pressure in conditions like glaucoma, and while it does have some action at alpha-1 receptors, its main effects are through alpha-2 receptor activation, which leads to reduced aqueous humor production and increased uveoscleral outflow. Apraclonidine is similar in its primary action and is also used in glaucoma management.

Naphazoline, while a topical agent used in the treatment of redness of the eye due to minor irritations, primarily targets alpha-1 receptors but is typically classified more for its sympathomimetic effects rather than specifically utilized in ocular applications like pupil dilation.

Thus, the unique recognition of Phenyle