What is the most common side effect of Bisphosphonates used for osteoporosis?

The most common side effect of bisphosphonates, which are primarily used in the treatment of osteoporosis, is indeed non-specific conjunctivitis. Bisphosphonates are generally well tolerated, but some patients may experience ocular side effects. Non-specific conjunctivitis refers to the inflammation of the conjunctiva that is not attributed to a specific pathogen or allergen, and can manifest as redness, itching, and discomfort.

While ocular side effects such as dry eye, diplopia, and cystoid macular edema may occur in some patients, they are much less prevalent when compared to non-specific conjunctivitis. The irritation or inflammation in the eyes may be related to the systemic effects of bisphosphonates or secondary to an allergic reaction. Nevertheless, the frequency and severity of these ocular conditions do not reach the levels seen with non-specific conjunctivitis, making it the most commonly reported issue associated with bisphosphonates in clinical practice.

Awareness of these potential side effects is important for healthcare providers when prescribing bisphosphonates, as they can help monitor and manage any adverse effects related to the medication.