What is one of the primary mechanisms of action for a medication like Brimonidine?

Brimonidine is primarily known for its ability to decrease aqueous humor production, which plays a crucial role in managing intraocular pressure in conditions like glaucoma. As an alpha-2 adrenergic agonist, Brimonidine stimulates alpha-2 receptors in the ciliary body, leading to a reduction in the amount of aqueous fluid produced. This mechanism is vital because excess aqueous humor can elevate intraocular pressure, potentially damaging the optic nerve.

In addition to reducing production, Brimonidine also has some effect on increasing uveoscleral outflow, but its primary and notable action remains the decrease in the production of aqueous humor. This makes it particularly effective as a therapeutic agent for lowering intraocular pressure in patients with elevated levels due to glaucoma or ocular hypertension.