What dosage of Pilocarpine is used to diagnose Adie's Tonic Pupil?

The dosage of 0.125% Pilocarpine is used to diagnose Adie's Tonic Pupil. This concentration is particularly effective because it allows enough drug to demonstrate the characteristic pharmacologic response associated with Adie's syndrome, which is a slow response to light and accommodation, along with a tonic pupil that reacts poorly to light but constricts well with near vision.

In Adie's Tonic Pupil, the affected pupil does not respond effectively to the autonomic nervous system. However, when a low concentration of Pilocarpine is administered, it can provoke a constriction response. The specific choice of 0.125% is optimal because it is low enough to avoid excessive constriction in normal pupils but strong enough to elicit a response in the affected pupil, indicating denervation supersensitivity typical of Adie's syndrome.

Higher concentrations of Pilocarpine may cause more significant side effects or reactions and can overwhelm the subtle differences in pupillary response that are needed for an accurate diagnosis. Therefore, while stronger concentrations can indeed cause pupil constriction, they do not serve the diagnostic purpose as effectively as the 0.125% solution does in the context of Adie's Tonic Pupil.