What does the pneumonic BEZPOP stand for in relation to topical mast cell/antihistamine combinations?

The mnemonic BEZPOP stands for a specific group of topical mast cell stabilizers and antihistamines used in the treatment of allergic conjunctivitis. In this context, the correct components are Bepotastine, Epinastine, Ketotifen, Olopatadine, and Azelastine. These medications all share a common function in managing allergic symptoms by stabilizing mast cells and blocking histamine receptors.

Bepotastine and Olopatadine are particularly noteworthy as they are dual-action agents that not only inhibit the release of mediators from mast cells but also block histamine H1 receptors, providing a broader therapeutic effect. Epinastine is known for its rapid onset in relieving allergic symptoms. Ketotifen is popular due to its long duration of action and once-daily dosing option. Azelastine is effective in providing relief and is available in both nasal and ophthalmic formulations, making it versatile in treating various allergic reactions.

This combination of five medications provides a robust approach to ocular allergies by addressing both the immediate and longer-term effects of histamine and other inflammatory mediators involved in allergic responses.