What complication can arise from the use of Apraclonidine over prolonged periods?

Apraclonidine is an alpha-2 adrenergic agonist that is primarily used to lower intraocular pressure in glaucoma management. One notable complication that can arise from prolonged use of apraclonidine is tachyphylaxis, which is a rapidly diminishing response to successive doses of a drug after its initial administration.

Tachyphylaxis occurs because the receptors become less responsive over time due to various mechanisms, such as receptor desensitization or downregulation. In the case of apraclonidine, after prolonged use, patients may find that their response to the medication diminishes, resulting in less effective control of intraocular pressure. This can lead clinicians to increase the dose or add additional medications, potentially complicating treatment and management of glaucoma.

Understanding this effect is crucial for effective long-term glaucoma management, as reliance on a medication that may lose efficacy can have significant implications for a patient’s ocular health.