What are the two topical Alpha 2 adrenergic agonists?

The two topical Alpha 2 adrenergic agonists are Apraclonidine and Brimonidine. Both medications are primarily used in the management of glaucoma and ocular hypertension.

Apraclonidine is often employed to reduce intraocular pressure, especially post-operatively, and it works by decreasing the production of aqueous humor and increasing uveoscleral outflow. Brimonidine also serves a similar purpose but is often favored due to its more selective action and a more favorable side effect profile, making it a common choice for long-term management of glaucoma.

Other options listed involve different classes of medications. Phenylephrine is primarily an Alpha 1 agonist used as a mydriatic agent, while atropine is an anticholinergic that affects the muscarinic receptors. Cyclopentolate and homatropine are also anticholinergic agents, used to induce mydriasis. Scopolamine has anticholinergic properties, primarily used for motion sickness, and tetrahydrozoline is a topical decongestant that acts on Alpha 1 receptors rather than being an Alpha 2 agonist. Thus, Apraclonidine and Brimonidine are confirmed as the correct topical Alpha 2 adrenergic agon