Roughly what percentage of aqueous outflow goes through the corneoscleral route?

The corneoscleral route is one of the two primary pathways for aqueous humor outflow in the eye, with the other being the uveoscleral route. In healthy eyes, approximately 80% of the aqueous humor passes through the corneoscleral pathway, which includes the trabecular meshwork and Schlemm's canal, facilitating drainage into the episcleral veins.

This estimate is critical for understanding how intraocular pressure (IOP) is regulated, as it emphasizes the importance of the corneoscleral pathway in maintaining the proper balance of aqueous humor production and outflow. Disruption in this route can lead to increased IOP and conditions such as glaucoma. Hence, recognizing that around 80% of the flow occurs through this pathway helps in grasping the dynamics of ocular pharmacology and the impact of certain medications on aqueous outflow.