Is Timolol usually dosed in the morning or at night?

Timolol is a non-selective beta-adrenergic antagonist frequently used as an ocular hypotensive agent in the management of glaucoma and intraocular pressure (IOP) reduction. The typical dosing schedule for Timolol is in the morning. This is primarily due to the fact that IOP levels often peak throughout the day, and administering Timolol in the morning helps to suppress this peak and provide optimal control during waking hours when patients are more active.

The pharmacological action of Timolol is effective for about 24 hours, but dosing in the morning aligns with the natural circadian rhythms of IOP fluctuations. Adherence to this schedule can enhance the medication’s effectiveness during the times when it is needed most, such as during periods of increased fluid production in the eye.

While some patients might occasionally be instructed to dose at night or possibly both morning and night depending on their specific needs, the standard recommendation is generally morning administration. Thus, in most cases, morning dosing is the most common practice for Timolol.