Does Pilocarpine act on the Corneoscleral or Uveoscleral outflow system?

Pilocarpine is a muscarinic agonist that primarily facilitates aqueous humor outflow by stimulating the contraction of the ciliary muscle, which results in a decrease in intraocular pressure. This mechanism is particularly effective in increasing the outflow of aqueous humor through the corneoscleral route.

The corneoscleral outflow system encompasses the conventional pathway that includes the trabecular meshwork and Schlemm's canal, allowing for the drainage of aqueous humor from the anterior chamber of the eye. By enhancing this outflow, pilocarpine effectively helps in managing conditions such as glaucoma.

In contrast, the uveoscleral outflow pathway represents a less conventional route for aqueous humor drainage, mainly influenced by factors such as the reduction of resistance in the scleral tissues and interfaces. While some medications are focused on enhancing both pathways, pilocarpine’s primary action is through the corneoscleral outflow system, making this the correct answer in the context of the question.