Carbonic anhydrase inhibitors help reduce aqueous production by targeting which compound?

Carbonic anhydrase inhibitors reduce aqueous humor production primarily by affecting the bicarbonate ion. These medications work by inhibiting the enzyme carbonic anhydrase, which facilitates the conversion of carbon dioxide and water into carbonic acid, subsequently leading to the dissociation of carbonic acid into bicarbonate and hydrogen ions.

In the ciliary body, bicarbonate ions play a crucial role in the secretion of aqueous humor because they help in maintaining the osmotic balance needed for fluid movement. When carbonic anhydrase is inhibited, there is a decrease in bicarbonate production, leading to reduced osmotic driving force for aqueous humor formation. This results in lower intraocular pressure, which is beneficial in the treatment of conditions such as glaucoma.

In summary, the correct choice emphasizes the central role of bicarbonate in the mechanism through which carbonic anhydrase inhibitors exert their effects on aqueous humor production.